Effectiveness of one tube osmotic fragility screening in detecting beta-thalassaemia trait.

Effectiveness of one tube osmotic fragility screening in detecting beta-thalassaemia trait.

The effectiveness of the one tube method of osmotic fragility with three buffered solutions (0.32% saline, 0.36% saline, and tyrode) as a screening test for beta-thalassaemia trait was evaluated in several groups of subjects from Greece, Yugoslavia, and Thailand. The results clearly demonstrated that 0.36% saline is the most sensitive and effective solution since it could detect 96 to 100% of h...

Screening for beta thalassaemia

Single Tube Osmotic Fragility Test: a Sensitive and Specific Test for Screening of Microcytosis

Aim and Objective: To evaluate usefulness of Single Tube Osmotic Fragility Test (SOFT) for detection of microcytosis and its further application for thalassemia trait screening. Background: Iron deficiency and thalassemia are common causes of microcytic anaemia in Pakistan. Easy microcytosis screening is necessary at a low resourced country like Pakistan, so that further investigations speciall...

Screening of antenatal patients in a multiethnic community for beta thalassaemia trait.

An investigation of the reliability of screening tests for beta thalassaemia trait in pregnant women was carried out as part of a programme to predict beta thalassaemia major in the fetus. Women with a mean corpuscular volume (MCV) of less than 83fl were examined further, and the reliability of various red cell indices as screening tests was assessed and compared. Over three years 696 women wer...

Evaluation of M/H ratio for screening of beta thalassaemia trait.

This study was done to evaluate the efficiency of M/H ratio between the percentages of microcytic and hypochromic cells as a screening procedure for thalassaemia trait in Pakistani population. A total of 150 subjects, were included in this study. The analysis of results revealed that M/H ratio is a very sensitive index for beta thalassaemia trait. The sensitivity, predictive value and diagnosti...